Understanding how Chlamydia trachomatis manipulates host cell processes
Functional characterization of Chlamydia trachomatis inclusion membrane proteins and their role in subversion of host vesicular trafficking
['FUNDING_R01'] · UNIVERSITY OF IOWA · NIH-10809713
This study looks at how the Chlamydia bacteria, which can cause serious health problems like infections and even blindness, tricks our cells into giving it the nutrients it needs to grow, and it hopes to find new ways to treat these infections.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF IOWA (nih funded) |
| Locations | 1 site (IOWA CITY, UNITED STATES) |
| Trial ID | NIH-10809713 on ClinicalTrials.gov |
What this research studies
This research investigates how the bacterium Chlamydia trachomatis, which causes significant health issues including blindness and sexually transmitted infections, interacts with host cells to acquire essential nutrients. The study focuses on specific proteins that Chlamydia uses to hijack the host's cellular machinery, particularly the vesicular trafficking pathways, to facilitate its growth and replication. By employing advanced genetic techniques, the researchers aim to uncover the mechanisms behind these interactions, which could lead to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Chlamydia trachomatis infections or those at high risk for such infections.
Not a fit: Patients with infections caused by other bacteria or those who do not have Chlamydia trachomatis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel treatments for infections caused by Chlamydia trachomatis, potentially reducing the incidence of related health complications.
How similar studies have performed: Previous research has shown success in understanding bacterial manipulation of host cell processes, indicating that this approach has potential for significant findings.
Where this research is happening
IOWA CITY, UNITED STATES
- UNIVERSITY OF IOWA — IOWA CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WEBER, MARY — UNIVERSITY OF IOWA
- Study coordinator: WEBER, MARY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: bacteria infection, bacterial disease, Bacterial Infections