Understanding how Chlamydia trachomatis invades human cells
The role of secreted effector proteins in Chlamydia trachomatis invasion
This study is looking at how the bacteria that cause Chlamydia, which can lead to blindness and is a common sexually transmitted infection, get into human cells, and it aims to find ways to stop these infections by understanding how the bacteria interact with our cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-10899746 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which Chlamydia trachomatis, a leading cause of non-congenital blindness and a common sexually transmitted infection, invades human cells. The study focuses on specific proteins that the bacteria use to manipulate the host's cellular structure, facilitating their entry. By examining how these proteins interact with host cell components, the research aims to uncover critical steps in the invasion process. This knowledge could lead to new strategies for preventing or treating infections caused by this pathogen.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk of Chlamydia trachomatis infection, particularly sexually active individuals and those with a history of sexually transmitted infections.
Not a fit: Patients who are not at risk for Chlamydia trachomatis infection or those who have already been effectively treated may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments or preventive measures against Chlamydia trachomatis infections, potentially reducing the incidence of blindness and other severe complications.
How similar studies have performed: Previous research has shown success in understanding bacterial invasion mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Weber, Mary — University of Iowa
- Study coordinator: Weber, Mary
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.