Understanding how Chlamydia interacts with host cells during its life cycle
Regulation and composition of ER-inclusion contacts at key stages of the Chlamydia developmental cycle
['FUNDING_R21'] · UNIVERSITY OF VIRGINIA · NIH-10528480
This study is looking at how the Chlamydia bacteria interacts with our cells to help it grow, which could lead to new ways to treat this common infection.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF VIRGINIA (nih funded) |
| Locations | 1 site (CHARLOTTESVILLE, UNITED STATES) |
| Trial ID | NIH-10528480 on ClinicalTrials.gov |
What this research studies
This research investigates the interactions between Chlamydia trachomatis, a common sexually transmitted infection, and the host's cellular environment. It focuses on how Chlamydia establishes contact with the endoplasmic reticulum, a crucial cellular structure, to facilitate its growth and replication. By examining the proteins involved in these interactions, the study aims to uncover the mechanisms that allow Chlamydia to thrive within host cells, which could lead to new treatment strategies. The research employs advanced cellular and molecular techniques to analyze these interactions throughout the bacterial developmental cycle.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Chlamydia trachomatis infections, particularly those experiencing asymptomatic cases.
Not a fit: Patients with other types of bacterial infections or those who are not infected with Chlamydia trachomatis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel therapeutic approaches for treating Chlamydia infections, potentially reducing long-term reproductive health issues.
How similar studies have performed: Previous research has shown success in understanding bacterial interactions with host cells, indicating that this approach may yield valuable insights.
Where this research is happening
CHARLOTTESVILLE, UNITED STATES
- UNIVERSITY OF VIRGINIA — CHARLOTTESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DERRE, ISABELLE — UNIVERSITY OF VIRGINIA
- Study coordinator: DERRE, ISABELLE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bacterial Infections, bacteria infection, bacterial disease