Understanding how childhood obesity affects the risk of a serious inflammatory condition in children after COVID-19.
Mechanisms of childhood obesity underlying the susceptibility to multisystem inflammatory syndrome in children (MIS-C)
This study is looking at how being overweight or obese might make kids more likely to get a serious condition called MIS-C after a COVID-19 infection, and it aims to find out why this happens so we can better protect and treat those kids.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10641777 on NIH RePORTER |
What this research studies
This research investigates the link between childhood obesity and the risk of developing Multisystem Inflammatory Syndrome in Children (MIS-C), a severe complication following SARS-CoV-2 infection. The study aims to uncover the mechanisms by which obesity may increase susceptibility to MIS-C, focusing on immune responses and genetic factors. By analyzing immune cell activation and inflammatory signaling in overweight and obese children, the research seeks to identify specific risk factors that contribute to more severe disease outcomes. The findings could help inform prevention strategies and treatment options for affected children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children who are overweight or obese and have experienced COVID-19 or its aftermath.
Not a fit: Children who are of normal weight and have not been affected by COVID-19 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of MIS-C in children, particularly those with obesity.
How similar studies have performed: Previous research has indicated a connection between obesity and severe inflammatory responses in children, suggesting that this study builds on established findings.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Chou, Janet — Boston Children's Hospital
- Study coordinator: Chou, Janet
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.