Understanding how childhood cancer treatments can lead to brain tumors
Official title: Determining the Origins and Vulnerabilities of Pediatric Treatment-Induced Gliomas
Funded at University of Colorado Denver · NIH-10982332 · Data updated 2026-11-12
This study is looking at why some children develop aggressive brain tumors after getting radiation treatment for other cancers, and it hopes to find ways to better treat these tumors by understanding their unique genetic features.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | August 15, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $474,337 |
| NIH project number | 1R01NS133339-01A1 |
| Project ID | NIH-10982332 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children who have previously undergone cranial radiotherapy for leukemia or other primary brain tumors.
✕Less likely to help
Patients who have not received cranial radiotherapy or who are not diagnosed with treatment-induced gliomas may not benefit from this research.
What this research studies
This research investigates the origins and vulnerabilities of high-grade gliomas that develop in children after they have received cranial radiotherapy for other cancers. By analyzing the genetic features of these tumors, the study aims to identify specific vulnerabilities that could be targeted with existing therapies. The research utilizes advanced techniques such as single-cell RNA sequencing and patient-derived cell models to explore how these tumors form and respond to treatment. The ultimate goal is to improve treatment options for affected children and reduce the incidence of these secondary tumors.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that significantly improve outcomes for children who develop treatment-induced brain tumors.
How similar studies have gone: Previous research has shown promise in understanding the genetic alterations in similar tumors, but this specific approach to treatment-induced gliomas is relatively novel.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Green, Adam Lyon — University of Colorado Denver
- Study coordinator: Green, Adam Lyon
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.