Understanding how chemicals like acrolein and phosgene cause lung injury
Official title: Pathophysiological Mechanisms of Chemical-Induced Acute Lung Injury
Funded at University of Cincinnati · NIH-10910056 · Data updated 2026-11-12
This study is looking at how breathing in certain harmful chemicals can hurt the lungs and cause breathing problems, and it aims to find out how these injuries happen and how different factors like age and genetics play a role, all to help create better treatments for people with serious lung issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | August 20, 2023 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $483,848 |
| NIH project number | 5R01ES034490-02 |
| Project ID | NIH-10910056 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced acute lung injury due to chemical exposure, particularly from smoke or chemical weapons.
✕Less likely to help
Patients with lung injuries not related to chemical exposure or those with chronic lung conditions may not benefit from this research.
What this research studies
This research investigates the harmful effects of inhaling chemicals such as acrolein and phosgene, which can lead to acute lung injury and respiratory distress. By studying the sequence of events that occur in the lungs after exposure to these chemicals, the researchers aim to identify the mechanisms that cause damage and influence recovery. The study uses mouse models to simulate human responses, allowing for a better understanding of how factors like age and genetics affect lung injury severity. The ultimate goal is to develop more effective treatments for patients suffering from acute respiratory distress syndrome (ARDS).
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for patients with acute lung injuries caused by chemical exposure.
How similar studies have gone: Previous research has shown promising results in understanding lung injuries from chemical exposure, but this specific investigation into acrolein and phosgene mechanisms is relatively novel.
Where this research is happening
-
University of Cincinnati
Cincinnati, United States Active
Researchers
- Principal investigator: Leikauf, George Douglas — University of Cincinnati
- Study coordinator: Leikauf, George Douglas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.