Understanding how chemical changes in RNA affect cytomegalovirus infection
EPITRANSCRIPTOMIC REGULATION OF CYTOMEGALOVIRUS INFECTION
This study is looking at how tiny changes in RNA can affect the way a virus called Human Cytomegalovirus (HCMV) behaves, which is important for understanding how it can cause problems, especially for pregnant women and newborns, and could help find new ways to treat infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10799626 on NIH RePORTER |
What this research studies
This research investigates the role of chemical modifications in RNA, specifically focusing on how the methylation of adenosine impacts gene expression and influences the biology of Human Cytomegalovirus (HCMV) infection. By examining these modifications, the research aims to uncover new insights into the mechanisms of HCMV, which is a significant cause of birth defects and severe disease in immunocompromised individuals. The study employs advanced molecular biology techniques to analyze how these modifications affect viral infection and host responses, potentially leading to new therapeutic strategies. Patients may benefit from a deeper understanding of HCMV and its effects, particularly in vulnerable populations such as pregnant women and newborns.
Who could benefit from this research
Good fit: Ideal candidates for this research include pregnant women, newborns, and individuals with weakened immune systems who are at risk for severe HCMV infection.
Not a fit: Patients who are not affected by cytomegalovirus or do not have conditions related to immune compromise may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cytomegalovirus infections, particularly in pregnant women and immunocompromised patients.
How similar studies have performed: Other research has shown promising results in understanding the role of RNA modifications in viral infections, suggesting that this approach could yield significant insights.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Mohr, Ian J — New York University School of Medicine
- Study coordinator: Mohr, Ian J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.