Understanding how changes in the Chd2 gene affect brain function and disorders.
Official title: Bidirectional control of Chd2 haploinsufficiency
Funded at University of California-Irvine · NIH-11012775 · Data updated 2026-11-12
This study is looking at how the Chd2 gene affects brain development in people with autism and epilepsy, using mice and human cells, to help find new treatments for those with changes in this gene.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $483,456 |
| NIH project number | 5R01NS126399-03 |
| Project ID | NIH-11012775 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with neurodevelopmental disorders, particularly those with known mutations in the Chd2 gene.
✕Less likely to help
Patients without neurodevelopmental disorders or those not carrying mutations in the Chd2 gene may not benefit from this research.
What this research studies
This research investigates the role of the Chd2 gene in neurodevelopmental disorders such as autism and epilepsy. By using advanced techniques in mice and human-derived neurons, the study aims to explore how varying levels of Chd2 can influence brain development and function. The researchers will employ a combination of cellular, molecular, and pharmacological methods to assess the impact of Chd2 on neuronal behavior and pathology. This could lead to new insights into potential therapies for conditions associated with Chd2 mutations.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies for individuals with Chd2 haploinsufficiency, potentially improving outcomes for those with neurodevelopmental disorders.
How similar studies have gone: Previous research has shown promising results in understanding the genetic basis of neurodevelopmental disorders, indicating that this approach could yield significant insights.
Where this research is happening
-
University of California-Irvine
Irvine, United States Active
Researchers
- Principal investigator: Hunt, Robert F — University of California-Irvine
- Study coordinator: Hunt, Robert F
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.