Understanding how cGAS affects breast cancer
Elucidating novel functions of cGAS in breast cancer
This study is looking at a protein called cGAS to see how it might affect the spread of breast cancer, with the goal of finding new ways to help prevent it from getting worse.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-10874707 on NIH RePORTER |
What this research studies
This research investigates the role of cGAS, a protein involved in the immune response, in breast cancer. It aims to uncover how cGAS functions beyond its known role in immunity, particularly in relation to breast cancer metastasis. By examining the levels of cGAS in different stages of breast cancer, the researchers hope to identify new therapeutic targets that could help prevent the spread of this disease. The study employs advanced techniques to analyze cellular mechanisms and gene expression related to cGAS.
Who could benefit from this research
Good fit: Ideal candidates for this research are women diagnosed with breast cancer, particularly those with metastatic disease.
Not a fit: Patients with non-breast cancers or those whose breast cancer is in the early stages without metastasis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that specifically target breast cancer metastasis, improving survival rates for patients.
How similar studies have performed: While the role of cGAS in immunity is well-established, its specific functions in breast cancer metastasis are still being explored, making this research a novel investigation.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Liu, Pengda — Univ of North Carolina Chapel Hill
- Study coordinator: Liu, Pengda
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.