Understanding how certain signals affect B cell tolerance in the immune system
Official title: Contribution and interplay of CXCR4 and integrins in central B cell tolerance
Funded at University of Colorado Denver · NIH-11087646 · Data updated 2026-11-12
This study is looking at how certain signals in the bone marrow affect the way B cells behave, especially how some of them might mistakenly attack the body and lead to autoimmune diseases, with the hope of finding new ways to help manage these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | May 10, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $568,467 |
| NIH project number | 5R01AI181854-02 |
| Project ID | NIH-11087646 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with autoimmune diseases who may have an increased number of autoreactive B cells.
✕Less likely to help
Patients without autoimmune conditions or those who do not have issues related to B cell tolerance may not benefit from this research.
What this research studies
This research investigates the mechanisms by which specific signaling pathways influence the selection of B cells in the bone marrow and their behavior in the immune system. It focuses on how these pathways may lead to the development of autoreactive B cells, which can contribute to autoimmune diseases. By studying the role of the CXCR4 receptor and integrins, the research aims to uncover how these signals affect the balance between healthy and self-reactive B cells. The findings could provide insights into potential therapeutic strategies for managing autoimmune conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that reduce the number of self-reactive B cells in patients, potentially improving outcomes for those with autoimmune diseases.
How similar studies have gone: Previous research has shown that targeting similar pathways can effectively modulate immune responses, suggesting a promising avenue for this investigation.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Pelanda, Roberta — University of Colorado Denver
- Study coordinator: Pelanda, Roberta
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.