Understanding how certain RNA structures affect protein production in neurological diseases
Official title: Mechanistic Basis for Non-Canonical Translation in Neurological Disease
Funded at State University of New York at Albany · NIH-11036871 · Data updated 2026-11-12
This study is looking into how certain RNA structures can change the way proteins are made in diseases linked to CAG repeat expansions, which often affect the nervous system, and it hopes to find new ways to help patients by understanding these processes better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Albany NIH-funded |
| Lab location | 1 site (Albany, United States) |
| Project start | January 1, 2023 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $241,397 |
| NIH project number | 4R00NS124994-03 |
| Project ID | NIH-11036871 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with CAG repeat expansion diseases, such as Huntington's disease.
✕Less likely to help
Patients with neurological disorders not related to CAG repeat expansions may not benefit from this research.
What this research studies
This research investigates the mechanisms behind non-canonical translation in diseases caused by CAG repeat expansions, which are common in neurological disorders. It focuses on how RNA structures can influence the production of proteins without the usual start signals. By using advanced techniques, the research aims to identify specific long non-coding RNAs that facilitate this process, potentially revealing new targets for therapeutic intervention. Patients may benefit from insights into how these mechanisms contribute to their conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating neurological diseases associated with CAG repeat expansions.
How similar studies have gone: While the specific approach of examining non-canonical translation in this context is relatively novel, similar studies have shown promise in understanding RNA's role in other genetic disorders.
Where this research is happening
-
State University of New York at Albany
Albany, United States Active
Researchers
- Principal investigator: Shorrock, Hannah — State University of New York at Albany
- Study coordinator: Shorrock, Hannah
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.