Understanding how certain receptors affect immune responses in B cells
Nuclear Receptors in B Cell Tolerance and Humoral Immune Responses
This study is looking at how certain proteins in our cells can help B cells, which are important for our immune system, respond better to germs, with the hope of finding new ways to improve vaccines and treatments for autoimmune diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10843078 on NIH RePORTER |
What this research studies
This research investigates the role of the Nr4a family of nuclear hormone receptors in regulating B cell responses to antigens. By manipulating these receptors, the study aims to enhance our understanding of B cell tolerance and improve treatments for autoimmune diseases. The approach involves using small molecule ligands to selectively influence B cell behavior in response to immune challenges. Patients may benefit from advancements in vaccination strategies and therapies for immune-mediated conditions.
Who could benefit from this research
Good fit: Ideal candidates include individuals with autoimmune diseases or those interested in novel immunotherapy approaches.
Not a fit: Patients with non-autoimmune conditions or those not affected by immune-mediated diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccination methods and treatments for autoimmune diseases.
How similar studies have performed: Previous research has shown promise in manipulating immune responses through similar receptor pathways, indicating potential for success in this approach.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Zikherman, Julie — University of California, San Francisco
- Study coordinator: Zikherman, Julie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.