Understanding how certain proteins signal in immune cells
Biochemical Determinants of Chemokine Receptor Signaling
This study is looking at how a specific immune receptor called CXCR3 works in our body's T cells, which could help us find new ways to treat autoimmune diseases that cause inflammation, potentially leading to better treatment options for patients.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10948605 on NIH RePORTER |
What this research studies
This research investigates the biochemical pathways of chemokine receptors, which are important for immune cell signaling. The focus is on a newly discovered signaling pathway related to the CXCR3 receptor, which plays a role in inflammation and immune responses. By using advanced techniques in protein purification and structural biology, the research aims to uncover how these receptors function in T cells, potentially leading to new therapeutic targets for autoimmune diseases. Patients may benefit from insights gained that could improve treatment options for conditions involving Th1-mediated inflammation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with autoimmune diseases that involve Th1-mediated inflammation.
Not a fit: Patients with conditions unrelated to immune signaling or those not affected by autoimmune diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for autoimmune diseases by targeting specific signaling pathways in immune cells.
How similar studies have performed: Other research has shown promise in targeting GPCRs for drug development, indicating that this approach could lead to significant advancements in treatment.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Smith, Jeffrey Scott — Brigham and Women's Hospital
- Study coordinator: Smith, Jeffrey Scott
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.