Understanding how certain proteins signal in immune cells
Official title: Biochemical Determinants of Chemokine Receptor Signaling
Funded at Brigham and Women's Hospital · NIH-10948605 · Data updated 2026-11-12
This study is looking at how a specific immune receptor called CXCR3 works in our body's T cells, which could help us find new ways to treat autoimmune diseases that cause inflammation, potentially leading to better treatment options for patients.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $163,514 |
| NIH project number | 1K08AR084617-01 |
| Project ID | NIH-10948605 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with autoimmune diseases that involve Th1-mediated inflammation.
✕Less likely to help
Patients with conditions unrelated to immune signaling or those not affected by autoimmune diseases may not benefit from this research.
What this research studies
This research investigates the biochemical pathways of chemokine receptors, which are important for immune cell signaling. The focus is on a newly discovered signaling pathway related to the CXCR3 receptor, which plays a role in inflammation and immune responses. By using advanced techniques in protein purification and structural biology, the research aims to uncover how these receptors function in T cells, potentially leading to new therapeutic targets for autoimmune diseases. Patients may benefit from insights gained that could improve treatment options for conditions involving Th1-mediated inflammation.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for autoimmune diseases by targeting specific signaling pathways in immune cells.
How similar studies have gone: Other research has shown promise in targeting GPCRs for drug development, indicating that this approach could lead to significant advancements in treatment.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Smith, Jeffrey Scott — Brigham and Women's Hospital
- Study coordinator: Smith, Jeffrey Scott
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.