Understanding how certain proteins regulate cell behavior in response to environmental signals
Regulatory Mechanisms of PP2A Family Phosphatases
This study is looking at how certain proteins in our cells help them respond to changes in their environment, which could help us understand diseases like cancer and metabolic disorders better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-10842977 on NIH RePORTER |
What this research studies
This research investigates the regulatory mechanisms of protein phosphatase 2A (PP2A) family phosphatases, which play a crucial role in how cells respond to their environment. By studying how these proteins interact with various environmental signals, the research aims to uncover the complexities of cellular signaling and behavior. The approach involves analyzing the dynamic nature of phosphatase complexes and their regulatory subunits, which are essential for determining how cells function and adapt. This work could lead to new insights into diseases where these processes go awry, such as cancer and metabolic disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to cellular signaling dysregulation, such as certain cancers or metabolic disorders.
Not a fit: Patients with conditions unrelated to cellular signaling or those who do not have a diagnosis of cancer or metabolic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases like cancer and diabetes by targeting the regulatory mechanisms of phosphatases.
How similar studies have performed: Previous research has shown promising results in understanding protein kinases, but the specific regulatory mechanisms of phosphatases are less explored, making this approach relatively novel.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Kong, Mei — University of California-Irvine
- Study coordinator: Kong, Mei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.