Understanding how certain proteins regulate cell behavior in response to environmental signals
Official title: Regulatory Mechanisms of PP2A Family Phosphatases
Funded at University of California-Irvine · NIH-10842977 · Data updated 2026-11-12
This study is looking at how certain proteins in our cells help them respond to changes in their environment, which could help us understand diseases like cancer and metabolic disorders better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project start | September 10, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $384,848 |
| NIH project number | 1R35GM153227-01 |
| Project ID | NIH-10842977 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to cellular signaling dysregulation, such as certain cancers or metabolic disorders.
✕Less likely to help
Patients with conditions unrelated to cellular signaling or those who do not have a diagnosis of cancer or metabolic disorders may not benefit from this research.
What this research studies
This research investigates the regulatory mechanisms of protein phosphatase 2A (PP2A) family phosphatases, which play a crucial role in how cells respond to their environment. By studying how these proteins interact with various environmental signals, the research aims to uncover the complexities of cellular signaling and behavior. The approach involves analyzing the dynamic nature of phosphatase complexes and their regulatory subunits, which are essential for determining how cells function and adapt. This work could lead to new insights into diseases where these processes go awry, such as cancer and metabolic disorders.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases like cancer and diabetes by targeting the regulatory mechanisms of phosphatases.
How similar studies have gone: Previous research has shown promising results in understanding protein kinases, but the specific regulatory mechanisms of phosphatases are less explored, making this approach relatively novel.
Where this research is happening
-
University of California-Irvine
Irvine, United States Active
Researchers
- Principal investigator: Kong, Mei — University of California-Irvine
- Study coordinator: Kong, Mei
Related research
Other NIH-funded projects on the same topics.
-
Retinal cell grafts to restore sight in AMD and RP
A patient-focused program aims to replace damaged retinal cells with organized, transplant-ready sheets created from stem cells to improve vision in age-related macular degeneration and related diseases.
-
Treg-based tolerance to dystrophin immune responses in Duchenne muscular dystrophy
A new grant aims to help people with Duchenne muscular dystrophy by teaching the immune system to tolerate the dystrophin treatment delivered by gene therapy.
-
Immune and NGF factors in Alzheimer’s for adults with Down syndrome
This grant studies why people with Down syndrome develop Alzheimer’s disease by looking at immune signals and nerve growth factor problems.
-
Promoting Heart Cell Maturation with Light-Activated Engineered Peptides
Aims to help grown heart cells from stem cells mature more like real adult heart tissue using special peptide coatings that respond to light.
-
Understanding how heart nerves affect dangerous heart rhythms after a heart attack
This NIH grant studies how changes in the heart’s nerve signaling after a heart attack lead to dangerous rhythm problems, with the goal of finding ways to prevent them.
-
All of Us Southern California Consortium supports broad participation in a national health data program
A national health data program in Southern California works to recruit and retain adults to share health information and participate in research that uses this data.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.