Understanding how certain proteins regulate blood clotting and cardiovascular diseases
Investigating the regulation and substrate processing of ADAMTS13 and ADAMTS7 metalloproteases
['FUNDING_OTHER'] · VERSITI WISCONSIN, INC. · NIH-11138782
This study is looking at how two proteins that help with blood clotting and heart health work, which could lead to better treatments for blood clotting disorders and heart disease.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VERSITI WISCONSIN, INC. (nih funded) |
| Locations | 1 site (MILWAUKEE, UNITED STATES) |
| Trial ID | NIH-11138782 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms that control two important proteins, ADAMTS13 and ADAMTS7, which play a role in blood clotting and cardiovascular health. By examining how these proteins are activated and interact with other molecules, the study aims to uncover insights into blood clotting disorders and atherosclerosis. The approach includes a combination of functional tests, structural analysis, and bioinformatics to identify key regulatory elements. Patients may benefit from improved understanding and potential new treatments for conditions related to blood clotting and cardiovascular diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with inherited or acquired blood clotting disorders or those at risk for cardiovascular diseases.
Not a fit: Patients with unrelated health conditions or those not affected by blood clotting or cardiovascular issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better treatments for blood clotting disorders and cardiovascular diseases.
How similar studies have performed: Previous research has shown success in understanding the roles of metalloproteases in cardiovascular diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
MILWAUKEE, UNITED STATES
- VERSITI WISCONSIN, INC. — MILWAUKEE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MUIA, JOSHUA MUTAMBUKI — VERSITI WISCONSIN, INC.
- Study coordinator: MUIA, JOSHUA MUTAMBUKI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Atherosclerotic Cardiovascular Disease, atherosclerotic coronary disease, atherosclerotic disease, atherosclerotic vascular disease