Understanding how certain proteins regulate blood clotting and cardiovascular diseases
Official title: Investigating the regulation and substrate processing of ADAMTS13 and ADAMTS7 metalloproteases
Funded at Versiti Wisconsin, INC. · NIH-11138782 · Data updated 2026-11-12
This study is looking at how two proteins that help with blood clotting and heart health work, which could lead to better treatments for blood clotting disorders and heart disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Versiti Wisconsin, INC. NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | August 1, 2021 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $412,500 |
| NIH project number | 5R35GM142926-05 |
| Project ID | NIH-11138782 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with inherited or acquired blood clotting disorders or those at risk for cardiovascular diseases.
✕Less likely to help
Patients with unrelated health conditions or those not affected by blood clotting or cardiovascular issues may not benefit from this research.
What this research studies
This research investigates the mechanisms that control two important proteins, ADAMTS13 and ADAMTS7, which play a role in blood clotting and cardiovascular health. By examining how these proteins are activated and interact with other molecules, the study aims to uncover insights into blood clotting disorders and atherosclerosis. The approach includes a combination of functional tests, structural analysis, and bioinformatics to identify key regulatory elements. Patients may benefit from improved understanding and potential new treatments for conditions related to blood clotting and cardiovascular diseases.
Why it matters
Potential benefit: If successful, this research could lead to better treatments for blood clotting disorders and cardiovascular diseases.
How similar studies have gone: Previous research has shown success in understanding the roles of metalloproteases in cardiovascular diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Versiti Wisconsin, INC.
Milwaukee, United States Active
Researchers
- Principal investigator: Muia, Joshua Mutambuki — Versiti Wisconsin, INC.
- Study coordinator: Muia, Joshua Mutambuki
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.