Understanding how certain proteins help prevent genomic instability
Official title: XRN2-DDX23 Cooperation in Avoiding R-loop-induced Genomic Instability
Funded at New Mexico Inst of Mining & Technology · NIH-10654331 · Data updated 2026-11-12
This study is looking at how two proteins, XRN2 and DDX23, help keep our DNA stable and healthy by stopping harmful structures that can lead to diseases like cancer and autoimmune disorders, with the hope of finding new ways to help people who have these conditions.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New Mexico Inst of Mining & Technology NIH-funded |
| Lab location | 1 site (Socorro, United States) |
| Project start | August 18, 2023 |
| Project end | July 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $355,584 |
| NIH project number | 1R15GM150071-01 |
| Project ID | NIH-10654331 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with autoimmune diseases or cancers that may be linked to genomic instability.
✕Less likely to help
Patients with conditions unrelated to genomic instability or those not affected by autoimmune diseases or cancers may not benefit from this research.
What this research studies
This research investigates the roles of specific proteins, XRN2 and DDX23, in maintaining genomic stability by preventing harmful structures called R-loops that can lead to diseases like cancer and autoimmune disorders. The study aims to explore how these proteins interact and contribute to DNA repair and cell survival. By understanding these mechanisms, the research seeks to identify potential therapeutic targets for improving health outcomes in patients affected by genomic instability-related conditions.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance DNA repair mechanisms, potentially reducing the risk of diseases like cancer and autoimmune disorders.
How similar studies have gone: Other research has shown promising results in understanding the roles of proteins in DNA repair, suggesting that this approach could yield valuable insights.
Where this research is happening
-
New Mexico Inst of Mining & Technology
Socorro, United States Active
Researchers
- Principal investigator: Patidar, Praveen — New Mexico Inst of Mining & Technology
- Study coordinator: Patidar, Praveen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.