Understanding how certain proteins help in biological processes
Official title: Structural mechanisms of multimeric ATPases
Funded at Univ of Massachusetts Med Sch Worcester · NIH-11011638 · Data updated 2026-11-12
This study is looking at how certain important proteins work to help with things like copying DNA and putting DNA into viruses, which could help us understand more about their roles in health and disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $669,281 |
| NIH project number | 1R35GM156361-01 |
| Project ID | NIH-11011638 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by bacterial infections or cancers, particularly those related to Burkitt lymphoma.
✕Less likely to help
Patients with conditions unrelated to bacterial infections or the specific mechanisms of ATPases may not benefit from this research.
What this research studies
This research investigates the structural mechanisms of multimeric ATPases, which are essential proteins that drive various biological functions, including DNA replication and virus assembly. The study focuses on two types of ATPases: one that acts as a powerful motor to pump DNA into viruses and another that functions as a switch to facilitate DNA replication. By examining the differences in how these proteins operate, the research aims to uncover the underlying principles that govern their diverse functions. This could lead to a better understanding of how these proteins contribute to health and disease.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies targeting bacterial infections and cancers, improving patient outcomes.
How similar studies have gone: Previous research has successfully elucidated the mechanisms of similar ATPases, indicating a promising avenue for further exploration.
Where this research is happening
-
Univ of Massachusetts Med Sch Worcester
Worcester, United States Active
Researchers
- Principal investigator: Kelch, Brian Anthony — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Kelch, Brian Anthony
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.