Understanding how certain proteins control gene activity and chromatin structure
Official title: Control and function of repressive chromatin domains
Funded at University of Georgia · NIH-11137574 · Data updated 2026-11-12
This study is looking at how certain proteins help control gene activity in a type of fungus, which could help us understand how changes in these processes might lead to developmental disorders and cancers in people.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Georgia NIH-funded |
| Lab location | 1 site (Athens, United States) |
| Project start | July 12, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $365,002 |
| NIH project number | 5R35GM152134-02 |
| Project ID | NIH-11137574 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic disorders like Weaver syndrome or those affected by specific types of cancer linked to chromatin modifications.
✕Less likely to help
Patients with conditions unrelated to chromatin modifications or those not affected by genetic disorders may not benefit from this research.
What this research studies
This research investigates the role of Polycomb Group proteins in modifying chromatin, which is crucial for regulating gene expression and maintaining stem cell identity. By using the model organism Neurospora crassa, the study aims to uncover the mechanisms behind the formation of repressed chromatin states that can lead to developmental disorders and cancers. The research employs a variety of techniques, including genetic, molecular, and genomic approaches, to explore how these proteins function and interact. The findings could provide insights into the genetic basis of diseases linked to chromatin modifications.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for diagnosing and treating cancers and genetic disorders associated with chromatin dysfunction.
How similar studies have gone: Previous research has shown success in understanding chromatin modifications and their implications in various diseases, indicating that this approach is built on a solid foundation of existing knowledge.
Where this research is happening
-
University of Georgia
Athens, United States Active
Researchers
- Principal investigator: Lewis, Zachary — University of Georgia
- Study coordinator: Lewis, Zachary
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.