Understanding how cells control signals and adhesion with the secretory pathway
Official title: Unraveling cellular interactions as regulated by the mammalian secretory pathway with systems biology and algorithm development
Funded at University of Georgia · NIH-11583050 · Data updated 2026-11-12
A funded NIH project looks at how the cell’s secretory system shapes signals, receptors, and attachment to the outside of the cell, which can influence many human diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Georgia NIH-funded |
| Lab location | 1 site (Athens, United States) |
| Project start | July 15, 2016 |
| Project end | June 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $350,319 |
| NIH project number | 7R35GM119850-11 |
| Project ID | NIH-11583050 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are patients with diseases linked to secretory pathway dysfunction or to abnormal protein secretion and cell signaling.
✕Less likely to help
People without related conditions may not directly benefit from this basic science work.
What this research studies
This project studies the mammalian secretory pathway and how its machinery affects the proteins cells use to communicate with and stick to their surroundings. Researchers will map which secretory components are needed for specific secreted and membrane proteins and how tissues differ in these requirements. By analyzing how these processes relate to hormone release, stress in the endoplasmic reticulum, and amyloid formation, the work aims to connect cellular biology to disease-relevant outcomes. The study uses systems biology and algorithm development to organize complex interactions and predict how changes in the secretory pathway impact cell behavior.
Why it matters
Potential benefit: If successful, this work could improve our understanding of diseases where protein secretion and cell signaling go awry, potentially guiding new therapies.
How similar studies have gone: Previous research has shown that secretory pathway dynamics influence disease-related protein production, but much remains unknown, making this approach promising yet exploratory.
Where this research is happening
-
University of Georgia
Athens, United States Active
Researchers
- Principal investigator: Lewis, Nathan Enoch — University of Georgia
- Study coordinator: Lewis, Nathan Enoch
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.