Understanding how certain proteins affect immune responses in health and disease
Official title: Mechanisms of STAT1 and STAT3 canonical and persistent activation in physiology and disease
Funded at University of Alabama at Birmingham · NIH-11104429 · Data updated 2026-11-12
This study is looking at how two proteins, STAT1 and STAT3, help our immune system fight infections and stay healthy, which could lead to better treatments for autoimmune diseases and infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | March 1, 2025 |
| Project end | February 28, 2030 |
| Funding year | 2025 |
| Award (this year) | $639,485 |
| NIH project number | 1R01AI191107-01 |
| Project ID | NIH-11104429 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with autoimmune conditions or those experiencing immune deficiencies.
✕Less likely to help
Patients with non-autoimmune related health issues or those not affected by immune system dysfunction may not benefit from this research.
What this research studies
This research investigates the roles of specific proteins, known as STAT1 and STAT3, in the immune system's ability to respond to infections and maintain health. By using advanced techniques like cryogenic electron microscopy, the study aims to uncover how these proteins are activated and transported into the cell nucleus, where they help regulate important immune functions. Patients may benefit from insights gained about how these proteins contribute to autoimmune diseases and infections, potentially leading to new treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for autoimmune diseases and better strategies for enhancing immune responses against infections.
How similar studies have gone: Previous research has shown promising results in understanding immune signaling pathways, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Cingolani, Gino — University of Alabama at Birmingham
- Study coordinator: Cingolani, Gino
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.