Understanding how certain proteins affect immune responses and cell death in skin cells.
Official title: C/EBPβ Regulation of the Type 1 IFN Response; Sensitizing Keratinocytes to Direct Activators of Cytosolic PRRs and DNA Damage-Induced Cell Death
Funded at North Carolina State University Raleigh · NIH-10886136 · Data updated 2026-11-12
This study is looking at how a protein called C/EBPβ helps skin cells respond to stress and fight off infections, which could lead to better treatments for conditions like cancer and autoimmune diseases that involve problems with cell death.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Carolina State University Raleigh NIH-funded |
| Lab location | 1 site (Raleigh, United States) |
| Project start | July 15, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $310,799 |
| NIH project number | 5R01AR081974-02 |
| Project ID | NIH-10886136 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with autoimmune diseases or conditions associated with abnormal cell death.
✕Less likely to help
Patients with conditions unrelated to immune response or cell death regulation may not benefit from this research.
What this research studies
This research investigates the role of the C/EBPβ protein in regulating immune responses and cell death in skin cells called keratinocytes. By studying how these cells respond to stressors like DNA damage and pathogens, the research aims to uncover mechanisms that could lead to better treatments for conditions linked to misregulated cell death, such as cancer and autoimmune diseases. The approach involves examining the activation of specific immune pathways and their effects on cell survival and death. Patients may benefit from insights that could lead to new therapeutic strategies targeting these pathways.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from conditions related to immune response and cell death, such as cancer and autoimmune diseases.
How similar studies have gone: Previous research has shown promising results in understanding immune responses and cell death pathways, suggesting that this approach could yield valuable insights.
Where this research is happening
-
North Carolina State University Raleigh
Raleigh, United States Active
Researchers
- Principal investigator: Hall, Jonathan Russell — North Carolina State University Raleigh
- Study coordinator: Hall, Jonathan Russell
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.