Understanding how certain proteins affect cell function and shape in diseases like Alzheimer's.
Official title: Arf Functional Landscapes
Funded at Rensselaer Polytechnic Institute · NIH-10833051 · Data updated 2026-11-12
This study is looking at tiny proteins that help control how cells communicate and move things around, which could help us understand more about conditions like Alzheimer's disease and how they affect our brain cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rensselaer Polytechnic Institute NIH-funded |
| Lab location | 1 site (Troy, United States) |
| Project start | September 1, 2020 |
| Project end | May 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $349,538 |
| NIH project number | 5R01GM137766-05 |
| Project ID | NIH-10833051 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related neurological disorders.
✕Less likely to help
Patients with non-neurological conditions or those not affected by Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates the role of ADP ribosylation factors (Arfs), which are small proteins that act as switches to control cell signaling and transport. By examining how these proteins function in different states, the research aims to uncover their impact on cellular processes such as organelle transport and cell shape, which are crucial in conditions like Alzheimer's disease. The study employs advanced techniques like NMR and fluorescence to analyze the dynamic behavior of these proteins and their interactions. Patients may benefit from insights gained about the molecular mechanisms underlying neurological diseases.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating Alzheimer's disease and other neurological conditions.
How similar studies have gone: Previous research has shown that understanding protein dynamics can lead to significant advancements in treating neurological diseases, suggesting this approach has potential for success.
Where this research is happening
-
Rensselaer Polytechnic Institute
Troy, United States Active
Researchers
- Principal investigator: Royer, Catherine a — Rensselaer Polytechnic Institute
- Study coordinator: Royer, Catherine a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.