Understanding how certain proteins affect cell function and shape in diseases like Alzheimer's.
Arf Functional Landscapes
['FUNDING_R01'] · RENSSELAER POLYTECHNIC INSTITUTE · NIH-10833051
This study is looking at tiny proteins that help control how cells communicate and move things around, which could help us understand more about conditions like Alzheimer's disease and how they affect our brain cells.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RENSSELAER POLYTECHNIC INSTITUTE (nih funded) |
| Locations | 1 site (TROY, UNITED STATES) |
| Trial ID | NIH-10833051 on ClinicalTrials.gov |
What this research studies
This research investigates the role of ADP ribosylation factors (Arfs), which are small proteins that act as switches to control cell signaling and transport. By examining how these proteins function in different states, the research aims to uncover their impact on cellular processes such as organelle transport and cell shape, which are crucial in conditions like Alzheimer's disease. The study employs advanced techniques like NMR and fluorescence to analyze the dynamic behavior of these proteins and their interactions. Patients may benefit from insights gained about the molecular mechanisms underlying neurological diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related neurological disorders.
Not a fit: Patients with non-neurological conditions or those not affected by Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating Alzheimer's disease and other neurological conditions.
How similar studies have performed: Previous research has shown that understanding protein dynamics can lead to significant advancements in treating neurological diseases, suggesting this approach has potential for success.
Where this research is happening
TROY, UNITED STATES
- RENSSELAER POLYTECHNIC INSTITUTE — TROY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ROYER, CATHERINE A — RENSSELAER POLYTECHNIC INSTITUTE
- Study coordinator: ROYER, CATHERINE A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease, Autoimmune Diseases