Understanding how certain proteins affect asthma inflammation
Official title: Mechanisms of HuR Overexpression in Asthmatic Endotypes
Funded at University of Michigan at Ann Arbor · NIH-10888135 · Data updated 2026-11-12
This study is looking at how certain proteins in your body affect inflammation in different types of asthma, which could help us understand why some people have more severe symptoms or don’t respond well to treatments, with the hope of finding better, more personalized therapies for you.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | July 14, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $195,000 |
| NIH project number | 5R21AI173487-02 |
| Project ID | NIH-10888135 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with asthma, particularly those with varying responses to current treatments.
✕Less likely to help
Patients with asthma who do not have significant inflammatory responses or those with non-allergic asthma may not benefit from this research.
What this research studies
This research investigates the role of RNA-binding proteins, specifically HuR and TTP family members, in regulating inflammation in different types of asthma. By focusing on how these proteins interact with messenger RNA, the study aims to uncover mechanisms that contribute to asthma severity and treatment resistance. Patients may benefit from insights gained about how their specific asthma type is influenced by these proteins, potentially leading to more targeted therapies. The research employs advanced molecular techniques to analyze the expression and stability of inflammatory genes in CD4+ T cells.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments tailored to specific asthma endotypes.
How similar studies have gone: Previous research has shown that targeting RNA-binding proteins can influence inflammatory responses, suggesting potential for success in this area.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Atasoy, Ulus — University of Michigan at Ann Arbor
- Study coordinator: Atasoy, Ulus
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.