Understanding how certain medications cause high blood pressure in older adults
Neural Mechanisms of Calcineurin Inhibitor-Induced Hypertension
['FUNDING_R01'] · UNIVERSITY OF TX MD ANDERSON CAN CTR · NIH-10669034
This study is looking at how certain medications used by transplant patients can affect the brain and lead to high blood pressure, with the goal of finding ways to help manage this side effect better for those patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TX MD ANDERSON CAN CTR (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10669034 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the central nervous system in high blood pressure caused by calcineurin inhibitors, which are medications often used in transplant patients. The study focuses on how these medications, like cyclosporine, affect the brain's sympathetic nervous system and contribute to persistent hypertension. By examining specific brain regions and their interactions with these drugs, the research aims to uncover the underlying mechanisms that lead to increased blood pressure. This could help in developing strategies to mitigate this side effect for patients who rely on these medications.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults who are taking calcineurin inhibitors for conditions such as rheumatoid arthritis or those who have undergone organ transplants.
Not a fit: Patients who are not on calcineurin inhibitors or those with hypertension due to other unrelated causes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved management of hypertension in patients taking calcineurin inhibitors, enhancing their overall health and quality of life.
How similar studies have performed: Previous research has shown that understanding the neural mechanisms of drug-induced hypertension can lead to significant advancements in treatment, indicating that this approach has potential for success.
Where this research is happening
HOUSTON, UNITED STATES
- UNIVERSITY OF TX MD ANDERSON CAN CTR — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PAN, HUI-LIN — UNIVERSITY OF TX MD ANDERSON CAN CTR
- Study coordinator: PAN, HUI-LIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases, autoimmune disorder