Understanding how certain immune cells help heal lung blood vessels after injury
Perivascular macrophages - a new player in regulating endothelial repair following lung vascular injury
['FUNDING_R01'] · UNIVERSITY OF ILLINOIS AT CHICAGO · NIH-11293386
This study is looking at how certain immune cells in the lungs help repair blood vessels after a serious lung injury called Acute Respiratory Distress Syndrome (ARDS), and it aims to find new ways to improve recovery for patients with this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ILLINOIS AT CHICAGO (nih funded) |
| Locations | 1 site (Chicago, UNITED STATES) |
| Trial ID | NIH-11293386 on ClinicalTrials.gov |
What this research studies
This research investigates the role of perivascular macrophages (PVMs) in the healing process of lung blood vessels following acute lung injury, specifically Acute Respiratory Distress Syndrome (ARDS). By using advanced imaging techniques, the study will observe how these immune cells interact with endothelial cells in live mouse models. The researchers will manipulate the presence of PVMs to understand their impact on blood vessel repair and regeneration. This could lead to new therapeutic strategies aimed at enhancing lung recovery in patients suffering from ARDS.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Acute Respiratory Distress Syndrome or those experiencing severe acute lung injury.
Not a fit: Patients with chronic lung conditions or those not experiencing acute lung injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that significantly improve recovery outcomes for patients with ARDS.
How similar studies have performed: While the role of macrophages in lung repair is being explored, this specific focus on perivascular macrophages in ARDS is relatively novel and has not been extensively tested.
Where this research is happening
Chicago, UNITED STATES
- UNIVERSITY OF ILLINOIS AT CHICAGO — Chicago, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHOU, BISHENG — UNIVERSITY OF ILLINOIS AT CHICAGO
- Study coordinator: ZHOU, BISHENG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acute Lung Injury, Acute Pulmonary Injury, Acute Respiratory Distress Syndrome, Adult Respiratory Distress Syndrome