Understanding how certain immune cells help control autoimmune responses
Official title: Development, stability, and antigen specificity of T follicular regulatory phenotype cells
Funded at University of Chicago · NIH-10996447 · Data updated 2026-11-12
This study is looking at special immune cells called T follicular regulatory (Tfr) cells to see how they help keep our immune system in check and prevent autoimmune diseases, which happen when the body mistakenly attacks itself.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | October 1, 2024 |
| Project end | September 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31AI186394-01 |
| Project ID | NIH-10996447 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with autoimmune diseases or those at risk of developing such conditions.
✕Less likely to help
Patients with non-autoimmune conditions or those who do not have any immune system-related issues may not benefit from this research.
What this research studies
This research investigates the role of T follicular regulatory (Tfr) cells in managing the immune response, particularly in relation to autoimmune diseases. It aims to understand how these cells develop, differentiate, and maintain their function outside of germinal centers, where B cells produce antibodies. By studying the life cycle of Tfr cells, the research seeks to uncover their contributions to preventing the overproduction of self-reactive antibodies that can lead to autoimmune conditions. This could involve various laboratory techniques, including cell analysis and adoptive transfer studies in animal models.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating autoimmune diseases by enhancing the regulation of immune responses.
How similar studies have gone: Previous research has indicated the importance of Tfr cells in regulating immune responses, suggesting that this approach has potential based on established findings.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Graham, Taylor — University of Chicago
- Study coordinator: Graham, Taylor
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.