Understanding how certain immune cells develop and function in response to tumors and chronic infections
Determinants of differentiation and maintenance of PD-1+ CD8 T cells
This study is looking at special immune cells that help fight tumors and long-lasting infections, to understand how they change and grow, with the hope of finding better treatments for people whose immune systems need a boost.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11090407 on NIH RePORTER |
What this research studies
This research investigates the behavior of specific immune cells known as PD-1+ CD8 T cells, which play a crucial role in fighting tumors and chronic infections. The study focuses on how these cells differentiate into various types, including memory-like and effector cells, and the signals that influence their development and maintenance. By examining the role of costimulatory molecules, the research aims to uncover mechanisms that could enhance immune responses in patients. This could lead to improved therapies for conditions where the immune system is not functioning optimally.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients with cancer or chronic infections who may benefit from improved immune therapies.
Not a fit: Patients with acute infections or those not experiencing immune dysfunction may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for cancer and chronic infections by enhancing the immune response.
How similar studies have performed: Previous research has shown promising results in enhancing immune responses through similar approaches, indicating potential for success in this area.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Kamphorst, Alice Oliffson — Icahn School of Medicine at Mount Sinai
- Study coordinator: Kamphorst, Alice Oliffson
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.