Understanding how certain immune cells develop and function
Transcriptional Regulation of Innate-Like T Cells
['FUNDING_R01'] · UNIVERSITY OF CHICAGO · NIH-11169889
This study is looking at how certain immune cells, which help protect your body, develop and learn their special jobs, and it’s for anyone interested in understanding more about how these cells work, especially in relation to autoimmune diseases and allergies.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-11169889 on ClinicalTrials.gov |
What this research studies
This research investigates the development and regulation of innate lymphocytes, which are crucial components of the immune system. By focusing on specific transcription factors and regulatory enhancers, the study aims to uncover how these cells acquire their unique properties during development in the bone marrow and thymus. The researchers utilize advanced techniques such as ATAC sequencing and CRISPR to manipulate and analyze these immune cells, providing insights into their roles in various immune responses. This work could lead to a better understanding of autoimmune diseases and allergies, potentially informing new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with autoimmune diseases or allergies who are interested in understanding the underlying mechanisms of their conditions.
Not a fit: Patients with non-immune related conditions or those not suffering from autoimmune diseases or allergies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for autoimmune diseases and allergies by enhancing our understanding of immune cell development.
How similar studies have performed: Previous research has shown promise in understanding immune cell regulation through similar epigenetic approaches, indicating potential for success in this area.
Where this research is happening
CHICAGO, UNITED STATES
- UNIVERSITY OF CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ESTERHAZY, DARIA — UNIVERSITY OF CHICAGO
- Study coordinator: ESTERHAZY, DARIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases