Understanding how certain immune cells develop and function
Official title: Transcriptional Regulation of CD4+ T Cell Differentiation and Diversified Memory
Funded at University of Alabama at Birmingham · NIH-10884495 · Data updated 2026-11-12
This study is looking at how certain immune cells, called CD4+ T cells, change and develop to help your body fight off illnesses, and it aims to find ways to improve treatments for autoimmune diseases and boost your immune system.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | July 7, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $507,907 |
| NIH project number | 5R01AI177467-02 |
| Project ID | NIH-10884495 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with autoimmune diseases or those interested in immune system function.
✕Less likely to help
Patients with non-autoimmune conditions or those not affected by immune system issues may not benefit from this research.
What this research studies
This research investigates the differentiation of CD4+ T cells, which are crucial for immune responses and long-term immunity. The study focuses on understanding how these cells transition from one type to another, particularly the role of specific markers like CXCR5. By utilizing advanced techniques such as RNA sequencing and fate-mapping in mice, the researchers aim to uncover the genetic and molecular pathways that regulate these processes. This knowledge could lead to better strategies for treating autoimmune diseases and enhancing immune responses.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for autoimmune diseases by enhancing our understanding of immune cell differentiation.
How similar studies have gone: Other research has shown promising results in understanding immune cell differentiation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Hu, Hui — University of Alabama at Birmingham
- Study coordinator: Hu, Hui
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.