Understanding how certain immune cells can prevent autoimmune diseases
Robust immune tolerance conferred by Foxp3 transcriptional regulation
This study is looking at how certain immune cells can help control other cells that mistakenly attack the body, which can cause autoimmune diseases, and it aims to find ways to make these helpful cells work better, potentially leading to improved treatments for people with these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-11001536 on NIH RePORTER |
What this research studies
This research investigates how regulatory T cells (Treg) can suppress harmful self-destructive T cells that lead to autoimmune diseases. The study aims to uncover the mechanisms that enhance the suppressive capacity of Treg cells, focusing on the role of the Foxp3 protein in their development and function. By examining the genetic and environmental factors that influence Treg cells, the research seeks to improve treatments for autoimmune conditions. Patients may benefit from insights that could lead to more effective therapies for managing their autoimmune diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autoimmune diseases who are 21 years or older.
Not a fit: Patients with non-autoimmune conditions or those under 21 years old may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for patients suffering from autoimmune diseases.
How similar studies have performed: Previous research has shown promising results in enhancing Treg function, suggesting that this approach may lead to significant advancements in treating autoimmune diseases.
Where this research is happening
Memphis, United States
- St. Jude Children's Research Hospital — Memphis, United States (Active)
Researchers
- Principal investigator: Feng, Yongqiang — St. Jude Children's Research Hospital
- Study coordinator: Feng, Yongqiang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.