Understanding how certain immune cells affect brain cancer growth and treatment
Official title: Elucidating the distinct roles of T cell-polarized microglia in glioblastoma suppression and progression
Funded at Salk Institute for Biological Studies · NIH-10906015 · Data updated 2026-11-12
This study is looking at how special immune cells in the brain, called microglia, can help or hurt glioblastoma, a tough type of brain cancer, to find better ways to treat it with new therapies that might work better for patients like you.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Salk Institute for Biological Studies NIH-funded |
| Lab location | 1 site (La Jolla, UNITED STATES) |
| Project start | August 1, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $41,466 |
| NIH project number | 5F31CA284773-02 |
| Project ID | NIH-10906015 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with glioblastoma, particularly those who have not responded well to current treatments.
✕Less likely to help
Patients with other types of brain tumors or those who are not diagnosed with glioblastoma may not benefit from this research.
What this research studies
This research investigates the roles of specialized immune cells called microglia in glioblastoma, a severe form of brain cancer. The study aims to explore how these cells can either suppress or promote tumor growth, particularly in response to new immune therapies. By identifying the factors that influence these immune cells, the research seeks to develop better treatment strategies that could enhance the effectiveness of existing therapies. Patients may benefit from insights that could lead to more effective treatments for glioblastoma.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and potentially longer survival for patients with glioblastoma.
How similar studies have gone: While there have been mixed results in targeting immune cells in glioblastoma, this approach is still considered novel and holds potential for breakthroughs in treatment.
Where this research is happening
-
Salk Institute for Biological Studies
La Jolla, United States Active
Researchers
- Principal investigator: Garcia-Rivera, Lizmarie — Salk Institute for Biological Studies
- Study coordinator: Garcia-Rivera, Lizmarie
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CD38-Driven Changes in Brain Tumor Metabolism and Immunity in Glioblastoma
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.