Understanding how certain fats affect heart disease development
SPHINGOLIPID BIOLOGY OF MACROPHAGE IN CORONARY ATHEROSCLEROSIS DEVELOPMENT AND PROGRESSION
This study is looking at how certain fats in the body, called sphingolipids, might affect heart health and the buildup of plaque in arteries, which can lead to heart attacks, and it could help find new ways to prevent or treat this condition for people at risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10754862 on NIH RePORTER |
What this research studies
This research investigates the role of sphingolipids, a type of fat molecule, in the development and progression of coronary atherosclerosis, a condition that can lead to heart attacks. By studying how these molecules influence inflammatory macrophages, which are immune cells involved in heart disease, the research aims to uncover new mechanisms that regulate sphingolipid metabolism. The team has developed a novel mouse model that mimics human coronary lesions, allowing them to explore how changes in sphingolipid levels affect heart health. This could lead to new insights into preventing or treating atherosclerosis in patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for coronary atherosclerosis, including those with high cholesterol, diabetes, or a family history of heart disease.
Not a fit: Patients who do not have risk factors for coronary atherosclerosis or existing cardiovascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better manage or prevent coronary atherosclerosis and related heart conditions.
How similar studies have performed: Previous research has shown that targeting lipid metabolism can lead to significant advancements in cardiovascular disease treatment, suggesting potential success for this novel approach.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Di Lorenzo, Annarita — Weill Medical Coll of Cornell Univ
- Study coordinator: Di Lorenzo, Annarita
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.