Understanding how certain cells help heal lung damage
Official title: Defining PRC2 complex epigenomic control in alveolar progenitor cells
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-10983305 · Data updated 2026-11-12
This study is looking at how certain cells in the lungs help with breathing and how damage to these cells can lead to serious lung problems like Acute Respiratory Distress Syndrome (ARDS), with the goal of finding new ways to help the lungs heal better after injuries, especially since more people are facing these issues due to COVID-19.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | December 15, 2022 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $523,395 |
| NIH project number | 5R01HL166245-03 |
| Project ID | NIH-10983305 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults who have experienced acute lung injuries or ARDS, particularly those recovering from severe respiratory conditions.
✕Less likely to help
Patients with chronic lung diseases unrelated to acute injuries or those who do not have a history of acute lung injury may not benefit from this research.
What this research studies
This research investigates the role of specific progenitor cells in the alveolar region of the lungs, which are crucial for gas exchange and oxygenation. It focuses on how damage to these cells contributes to conditions like Acute Respiratory Distress Syndrome (ARDS), a serious lung condition affecting many patients. By studying the mechanisms behind lung recovery, the research aims to identify new regenerative therapies that could improve healing after acute lung injuries, especially in the context of increased cases due to the coronavirus pandemic.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that enhance recovery from acute lung injuries and improve long-term lung health for affected patients.
How similar studies have gone: While the specific mechanisms of recovery in ARDS are not well understood, similar research approaches have shown promise in other areas of regenerative medicine.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Zacharias, William John — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Zacharias, William John
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.