Understanding how certain cells contribute to artery calcification
Novel molecular mechanisms of vascular smooth muscle cell-mediated large and small artery calcification
This study is looking at how problems with a process called autophagy in certain cells can cause calcium buildup in arteries, which is important for understanding heart diseases, and it hopes to find new ways to help patients with these conditions.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10850677 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms behind vascular calcification, which is a significant factor in cardiovascular diseases like atherosclerosis. The study focuses on how the dysregulation of autophagy in vascular smooth muscle cells can lead to increased calcification in arteries. By using advanced techniques such as ATAC sequencing, the researchers aim to identify specific pathways that could be targeted for therapeutic intervention. Patients may benefit from insights gained that could lead to new treatments for cardiovascular conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cardiovascular diseases, particularly those affected by atherosclerosis or related conditions.
Not a fit: Patients with non-cardiovascular conditions or those without any signs of vascular calcification may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent or reduce artery calcification, improving cardiovascular health.
How similar studies have performed: Previous research has shown that targeting autophagy pathways can be beneficial in managing cardiovascular diseases, indicating a promising approach.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Lino Cardenas, Christian Lacks — Massachusetts General Hospital
- Study coordinator: Lino Cardenas, Christian Lacks
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.