Understanding how certain brain neurons regulate sympathetic nerve activity
Official title: Mechanisms of Synaptic Homeostasis Governing Pre-Sympathetic Neurons in the Hypothalamic Paraventricular Nucleus
Funded at Texas A&m University Health Science Ctr · NIH-11137377 · Data updated 2026-11-12
This study is looking at how certain brain cells help control important body functions by managing nerve activity, which can be affected by stress and might lead to issues like high blood pressure, and it aims to find out how these cells keep everything balanced.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m University Health Science Ctr NIH-funded |
| Lab location | 1 site (College Station, United States) |
| Project start | June 1, 2024 |
| Project end | May 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $466,775 |
| NIH project number | 7R01NS115072-05 |
| Project ID | NIH-11137377 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would include individuals experiencing autonomic dysfunction or related cardiovascular issues.
✕Less likely to help
Patients with conditions unrelated to sympathetic nerve activity or those not experiencing autonomic dysfunction may not benefit from this research.
What this research studies
This research investigates the mechanisms by which pre-sympathetic neurons in the hypothalamic paraventricular nucleus control sympathetic nerve activity, which is crucial for maintaining bodily functions. The study focuses on the role of synaptic inhibition and how certain factors can disrupt the resting state of these neurons, potentially leading to increased sympathetic activity. By exploring a novel mechanism called Glutamate-GABA strengthening, the research aims to uncover how these neurons maintain their balance and respond to stressors. This could provide insights into conditions related to autonomic dysfunction and hypertension.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for conditions related to autonomic dysfunction and hypertension by targeting the mechanisms that regulate sympathetic nerve activity.
How similar studies have gone: While the specific mechanism being studied is novel, previous research has shown success in understanding synaptic regulation in other contexts, suggesting potential for impactful findings.
Where this research is happening
-
Texas A&m University Health Science Ctr
College Station, United States Active
Researchers
- Principal investigator: Toney, Glenn M — Texas A&m University Health Science Ctr
- Study coordinator: Toney, Glenn M
Related research
Other NIH-funded projects on the same topics.
-
Dose-Dependent Brain Wire Modulation with Light Ultrasound in Deep White Matter
A small early study tests whether gentle, noninvasive ultrasound can change how deep brain white matter tracts work in healthy adults.
-
Automated self-acceptance training plus ketamine to extend antidepressant benefits
A study tests whether adding a quick computerized self-positivity training after ketamine can prolong relief from depression for people seeking ketamine treatment.
-
Ultrasound-guided brain circuit targets for treatment-resistant depression
This grant tests whether focused ultrasound can safely and reversibly adjust brain circuits linked to negative mood in people with treatment-resistant depression.
-
Back-Support Exoskeletons to Reduce Low Back Pain in Commercial Fishermen
A real-world trial will test whether wearable back-support exoskeletons can lower back pain and fatigue for commercial fishers on their boats.
-
Esophageal cancer start and immune changes
Researchers are studying how a specific cell type appears early in esophageal cancer and how it changes the surrounding immune environment, aiming to stop cancer before it grows.
-
Cholinergic Dysregulation and Cognitive Flexibility in Cocaine Use Disorder
A research study explores how cocaine changes brain signaling to affect flexible thinking and decision-making in people with cocaine use disorder.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.