Understanding how certain blood cell mutations can lead to leukemia
Mechanisms and therapeutic implications of human clonal hematopoiesis (CH) mutations
['FUNDING_R01'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-11098445
This study is looking into clonal hematopoiesis, a condition that can lead to blood cancers like leukemia, to help understand how certain changes in blood stem cells happen, which could eventually help in finding ways to detect and treat these cancers earlier for patients at risk.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11098445 on ClinicalTrials.gov |
What this research studies
This research investigates clonal hematopoiesis (CH), a condition where certain blood stem cells expand and carry mutations that may lead to blood cancers like acute myeloid leukemia (AML). By using advanced models, including human induced pluripotent stem cells, the study aims to uncover the molecular mechanisms behind these mutations and their role in the development of leukemia. Patients may benefit from insights that could lead to early detection and targeted therapies for those at risk of developing these malignancies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with clonal hematopoiesis or those at risk for developing myeloid malignancies.
Not a fit: Patients who do not have clonal hematopoiesis or are not at risk for myeloid malignancies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved early detection and treatment strategies for patients at risk of developing acute myeloid leukemia.
How similar studies have performed: Other research has shown promise in understanding clonal hematopoiesis and its implications for blood cancers, indicating that this approach is building on established findings.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PAPAPETROU, EIRINI — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: PAPAPETROU, EIRINI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Advanced Cancer