Understanding how certain blood cell mutations affect heart disease in older adults
Official title: Investigating the Pathological Features of Clonal Hematopoiesis-derived Macrophages
Funded at Stanford University · NIH-10771273 · Data updated 2026-11-12
This study is looking at how certain changes in blood cells, which are common in older adults and linked to heart disease, might cause inflammation and heart problems, with the goal of finding better ways to prevent and treat heart issues for seniors.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | February 1, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $155,667 |
| NIH project number | 5K99HL166780-02 |
| Project ID | NIH-10771273 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults, particularly those over the age of 70, who have been diagnosed with clonal hematopoiesis.
✕Less likely to help
Patients who are younger than 70 or do not have clonal hematopoiesis may not benefit from this research.
What this research studies
This research investigates a condition known as clonal hematopoiesis of indeterminate potential (CHIP), which is common in older adults and linked to an increased risk of heart disease. The study aims to explore how mutations in blood cells contribute to inflammation and cardiovascular issues by using human models and specialized mouse models. By examining the behavior of macrophages, a type of immune cell, the research seeks to uncover the mechanisms that lead to heart problems in individuals with CHIP. This could provide insights into better prevention and treatment strategies for heart disease in the elderly.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of heart disease in older adults with CHIP.
How similar studies have gone: Previous research has shown promising results in understanding the link between CHIP and cardiovascular disease, indicating that this approach has potential for significant findings.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Mitchell, Shaneice R. — Stanford University
- Study coordinator: Mitchell, Shaneice R.
Related research
Other NIH-funded projects on the same topics.
-
Multimodal AI to predict CAR-T patient response and guide safer, smarter cell design
A Stanford team is building AI tools that use patient and CAR-T cell data to predict how well a CAR-T therapy will work and what design changes might boost effectiveness and safety for people with cancer.
-
Community-driven model to reduce overdose deaths through smarter resource use
A Stanford-led project uses a data-driven model to help counties pick the best ways to prevent opioid and stimulant overdoses and save lives.
-
Center for Dissemination and Implementation at Stanford: Research Core
A Stanford-based program is advancing how evidence-based addiction treatments are implemented across settings to help people with substance use disorders receive better care.
-
Center for Dissemination and Implementation At Stanford (C-DIAS)
A center-based program at Stanford aims to speed people who need addiction treatments to get evidence-based care.
-
Mitochondrial structure and neuron health in Alzheimer's and ALS
This grant studies how mitochondrial cristae structure in neurons is controlled and how its disruption may contribute to diseases like Alzheimer's and ALS.
-
Pediatric EMS seizures: simpler age-based midazolam dosing
A nationwide trial at EMS agencies tests whether using fixed, age-based dosing of midazolam for seizures in children improves treatment speed and safety.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.