Understanding how certain blood cell mutations affect heart disease in older adults
Investigating the Pathological Features of Clonal Hematopoiesis-derived Macrophages
This study is looking at how certain changes in blood cells, which are common in older adults and linked to heart disease, might cause inflammation and heart problems, with the goal of finding better ways to prevent and treat heart issues for seniors.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10771273 on NIH RePORTER |
What this research studies
This research investigates a condition known as clonal hematopoiesis of indeterminate potential (CHIP), which is common in older adults and linked to an increased risk of heart disease. The study aims to explore how mutations in blood cells contribute to inflammation and cardiovascular issues by using human models and specialized mouse models. By examining the behavior of macrophages, a type of immune cell, the research seeks to uncover the mechanisms that lead to heart problems in individuals with CHIP. This could provide insights into better prevention and treatment strategies for heart disease in the elderly.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those over the age of 70, who have been diagnosed with clonal hematopoiesis.
Not a fit: Patients who are younger than 70 or do not have clonal hematopoiesis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of heart disease in older adults with CHIP.
How similar studies have performed: Previous research has shown promising results in understanding the link between CHIP and cardiovascular disease, indicating that this approach has potential for significant findings.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Mitchell, Shaneice R. — Stanford University
- Study coordinator: Mitchell, Shaneice R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.