Understanding how certain bacterial traits lead to antibiotic treatment failures.
Collateral Consequences of Enabler Genotypes in Antibiotic Treatment Failure.
['FUNDING_OTHER'] · BOSTON CHILDREN'S HOSPITAL · NIH-10911823
This study is looking into why some antibiotics don't work as well as they should by exploring certain traits in bacteria that help them resist treatment, with the goal of finding ways to make antibiotics more effective for patients like you.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON CHILDREN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10911823 on ClinicalTrials.gov |
What this research studies
This research investigates the reasons behind antibiotic treatment failures, focusing on specific bacterial traits known as 'enablers' that allow bacteria to evade antibiotic effects. By examining how these enabler genotypes contribute to antibiotic tolerance and resistance, the study aims to identify genetic factors that can be targeted to improve treatment outcomes. The research employs a combination of genetic analysis and experimental methods to explore these mechanisms, ultimately seeking to enhance the effectiveness of antibiotic therapies for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients with bacterial infections who have experienced treatment failures or are at risk of antibiotic resistance.
Not a fit: Patients with viral infections or those who have not been treated with antibiotics may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for treating bacterial infections, reducing the incidence of antibiotic treatment failures.
How similar studies have performed: Previous research has shown promise in understanding bacterial resistance mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON CHILDREN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ROSCH, JASON W. — BOSTON CHILDREN'S HOSPITAL
- Study coordinator: ROSCH, JASON W.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bacterial Infections