Understanding how certain bacteria develop resistance to antibiotics
Official title: An Analysis of ICE R391 Pathogen-encoded Rum DNA Polymerase in Generating Mutations Driving Rapid Acquisition of Antibiotic Drug Resistance in Diverse Recipient Bacterial Species
Funded at University of Southern California · NIH-11019315 · Data updated 2026-11-12
This study is looking at how certain bacteria become resistant to antibiotics by changing their DNA, and it’s for anyone interested in understanding how these changes help bacteria survive treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project start | March 17, 2025 |
| Project end | January 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $535,316 |
| NIH project number | 1R01ES036941-01 |
| Project ID | NIH-11019315 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with infections caused by antibiotic-resistant bacteria.
✕Less likely to help
Patients with infections that are not caused by bacterial pathogens or those who do not have antibiotic-resistant infections may not benefit from this research.
What this research studies
This research investigates how specific bacteria acquire resistance to antibiotics through mutations driven by a unique DNA polymerase known as Rum pol. By analyzing the mechanisms of mutation and the role of a protein called RecA, the study aims to uncover how these changes enable bacteria to survive antibiotic treatments. The research will involve laboratory experiments to observe the effects of Rum pol on various bacterial species, providing insights into the genetic factors that contribute to antibiotic resistance.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for combating antibiotic resistance in bacterial infections.
How similar studies have gone: Previous research has shown that understanding the genetic mechanisms of antibiotic resistance can lead to significant advancements in treatment options, indicating that this approach has potential for success.
Where this research is happening
-
University of Southern California
Los Angeles, United States Active
Researchers
- Principal investigator: Goodman, Myron — University of Southern California
- Study coordinator: Goodman, Myron
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.