Understanding how certain B cells behave in patients with partial RAG deficiency
Mechanisms driving extrafollicular polyreactive B cell lineages in partial RAG deficiency
This study is looking at how certain immune cells called B cells behave in people with a condition that makes their immune system weaker, to better understand how these cells might contribute to ongoing infections and autoimmune issues, with the hope of finding ways to boost their antibody responses.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-10911909 on NIH RePORTER |
What this research studies
This research investigates the behavior of specific B cell populations in patients with partial recombinase activating gene (RAG) deficiency, a condition that leads to immune system vulnerabilities. The study focuses on how these B cells, which can become autoreactive, respond to chronic infections and contribute to autoimmune disorders. By examining the interactions between hyperactive T follicular helper cells and extrafollicular polyreactive B cells, the research aims to uncover mechanisms that could improve antibody responses in affected individuals. The approach includes analyzing the immune response dynamics and the role of chronic antigen exposure in these patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with partial RAG deficiency or related congenital immunodeficiencies.
Not a fit: Patients without any form of immunodeficiency or those with unrelated autoimmune disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with congenital immunodeficiencies, enhancing their ability to fight infections and manage autoimmune conditions.
How similar studies have performed: Previous research has shown promising results in understanding B cell behavior in autoimmune conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
Tampa, United States
- University of South Florida — Tampa, United States (Active)
Researchers
- Principal investigator: Walter, Jolan Eszter — University of South Florida
- Study coordinator: Walter, Jolan Eszter
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.