Understanding how cellular signals affect tooth enamel formation
Official title: Redox and Ca2+ signaling regulation of enamel mineralization
Funded at New York University · NIH-11097292 · Data updated 2026-11-12
This study is looking at how certain cells help make dental enamel and how things like genetics and the environment can affect this process, especially for people with conditions like Down syndrome or dental fluorosis, to find ways to improve their dental health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | March 10, 2023 |
| Project end | February 28, 2028 |
| Funding year | 2025 |
| Award (this year) | $469,362 |
| NIH project number | 5R01DE027679-07 |
| Project ID | NIH-11097292 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation include individuals with Down syndrome or those affected by dental fluorosis, particularly those under 21 years old.
✕Less likely to help
Patients without enamel defects or those not affected by the studied conditions may not benefit from this research.
What this research studies
This research investigates the processes involved in the formation of dental enamel, focusing on how mitochondrial function and cellular signaling impact enamel mineralization. The study aims to understand how these processes are affected by environmental factors, particularly in individuals with genetic disorders like Down syndrome and conditions such as dental fluorosis. By examining the role of ameloblasts, the cells responsible for enamel production, the research seeks to uncover the mechanisms that lead to enamel defects and how these can be addressed. Patients may be involved in assessments that explore the relationship between their dental health and mitochondrial function.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for enamel defects, enhancing dental health and reducing the risk of tooth decay.
How similar studies have gone: Previous research has shown promising results in understanding the role of mitochondrial function in various cellular processes, suggesting potential for success in this area as well.
Where this research is happening
-
New York University
New York, United States Active
Researchers
- Principal investigator: Lacruz, Rodrigo S. — New York University
- Study coordinator: Lacruz, Rodrigo S.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.