Understanding how cellular clocks control cell division and function
Official title: Decoding the fundamental principles of autonomous clocks: mechanism, design and function
Funded at University of California, San Francisco · NIH-10685116 · Data updated 2026-11-12
This study is looking into how tiny internal clocks in our cells help them work properly, especially when they grow and divide, and the findings could help us understand and treat diseases caused by cell problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 20, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $1,453,500 |
| NIH project number | 1DP2GM154328-01 |
| Project ID | NIH-10685116 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with conditions related to cell cycle dysregulation, such as certain cancers.
✕Less likely to help
Patients with conditions unrelated to cellular processes or those not involving cell division may not receive any benefit from this research.
What this research studies
This research investigates the mechanisms behind autonomous cellular clocks that regulate various cellular processes, particularly during the cell cycle. It aims to uncover how these clocks operate independently and how they synchronize with the master clock of the cell cycle. By employing advanced techniques, the research will explore the roles of these clocks in cellular metabolism, organelle formation, and ensuring accurate cell division. Patients may benefit from insights gained into cellular dysfunctions related to diseases.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases linked to cell cycle misregulation.
How similar studies have gone: While the concept of autonomous cellular clocks is emerging, this research explores novel aspects that have not been extensively tested in previous studies.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Aydogan, Mustafa Gonenc — University of California, San Francisco
- Study coordinator: Aydogan, Mustafa Gonenc
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.