Understanding how cells transport ions and lipids across membranes
Official title: Advancing mechanistic understanding of membrane ion and lipid transport
Funded at Duke University · NIH-11078764 · Data updated 2026-11-12
This study is looking at how certain proteins help move important substances in and out of cells, which could help us understand and improve treatments for conditions like heart attacks, strokes, and infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | May 1, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $430,058 |
| NIH project number | 5R35GM153196-02 |
| Project ID | NIH-11078764 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals affected by conditions such as heart disease, stroke, epilepsy, muscular dystrophy, cancer, and infections like AIDS.
✕Less likely to help
Patients with conditions unrelated to membrane transport or those not affected by the diseases studied may not benefit from this research.
What this research studies
This research investigates the mechanisms by which ions and phospholipids move across cell membranes, focusing on a specific family of proteins known as TMEM16. These proteins play crucial roles in various diseases, including heart attacks, strokes, and infections like AIDS. By studying how these proteins function, the research aims to uncover new insights into cellular signaling and develop methods to monitor and control lipid movement in cells. This could lead to a better understanding of how these processes affect health and disease.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases related to membrane transport dysfunction, improving patient outcomes.
How similar studies have gone: Previous research has shown promising results in understanding membrane transport mechanisms, suggesting that this approach could yield significant insights.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Yang, Huanghe — Duke University
- Study coordinator: Yang, Huanghe
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.