Understanding how cells store energy in lipid droplets
Official title: Mechanisms of energy storage in lipid droplets
Funded at Sloan-Kettering Inst Can Research · NIH-11090627 · Data updated 2026-11-12
This study is looking at how our cells store energy in tiny fat droplets, which is important for keeping our energy levels balanced, and it aims to find out more about the genes and proteins involved in making these droplets, which could help develop new treatments for related health issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | June 1, 2025 |
| Project end | May 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $609,493 |
| NIH project number | 1R35GM158244-01 |
| Project ID | NIH-11090627 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with metabolic disorders, particularly those related to lipid metabolism and cardiovascular diseases.
✕Less likely to help
Patients with non-metabolic conditions or those not affected by lipid storage disorders may not benefit from this research.
What this research studies
This research investigates the mechanisms by which cells store energy in lipid droplets, which are essential for maintaining energy balance. The team will explore the genetic components and protein machinery involved in the formation of these droplets, focusing on key enzymes and their roles in lipid synthesis. By utilizing advanced biochemical techniques and molecular simulations, the researchers aim to uncover the structural and functional aspects of lipid droplet formation, which could lead to new therapeutic targets for related diseases.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for conditions related to energy storage, such as fatty liver disease and atherosclerosis.
How similar studies have gone: Previous research has shown promising results in understanding lipid metabolism, indicating that this approach could yield significant insights.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Farese, Robert V — Sloan-Kettering Inst Can Research
- Study coordinator: Farese, Robert V
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.