Understanding how cells sense their environment to improve wound healing and immune response
Extracellular matrix sensing in cellular signaling, migration and wound repair
This study is looking at how cells communicate with their environment to help heal wounds and fight inflammation, which could lead to better treatments for conditions like autoimmune diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Henry M. Jackson Fdn for the Adv Mil/med NIH-funded |
| Lab location | 1 site (Bethesda, United States) |
| Project ID | NIH-10683185 on NIH RePORTER |
What this research studies
This research investigates how cells interact with their surrounding extracellular matrix (ECM) and how these interactions influence immune responses and wound healing. By focusing on a process called 'haptosensing', the study aims to uncover the molecular mechanisms that regulate macrophage activation, which is crucial for healing and fighting inflammation. The researchers will conduct experiments to evaluate these processes at both cellular and molecular levels, and they will also apply their findings to real-life wound healing scenarios. This work could lead to new treatments for autoimmune diseases and chronic inflammation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with autoimmune diseases or chronic inflammatory conditions.
Not a fit: Patients without autoimmune diseases or chronic inflammatory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating autoimmune diseases and improving wound healing.
How similar studies have performed: Previous research has shown promising results in understanding the role of ECM in immune responses, suggesting that this approach could yield significant insights.
Where this research is happening
Bethesda, United States
- Henry M. Jackson Fdn for the Adv Mil/med — Bethesda, United States (Active)
Researchers
- Principal investigator: Rotty, Jeremy — Henry M. Jackson Fdn for the Adv Mil/med
- Study coordinator: Rotty, Jeremy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.