Understanding how cells respond to signals that affect gene expression
Single cell, genome wide dissection of dynamic transcription factor regulation
['FUNDING_FELLOWSHIP'] · NORTH CAROLINA STATE UNIVERSITY RALEIGH · NIH-10853084
This study is looking at how cells can respond to different signals and control gene activity, which is important for understanding diseases like cancer and autoimmune disorders, and it uses cool techniques to learn more about how these processes work.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTH CAROLINA STATE UNIVERSITY RALEIGH (nih funded) |
| Locations | 1 site (RALEIGH, UNITED STATES) |
| Trial ID | NIH-10853084 on ClinicalTrials.gov |
What this research studies
This research investigates how cells manage to respond to various signals and execute different gene expression programs despite having a limited number of signaling components. By using advanced techniques like optogenetics and single-cell RNA sequencing, the study aims to uncover the dynamics of transcription factors and their role in regulating gene expression. This could lead to a better understanding of diseases such as autoimmune disorders and cancer, where signaling pathways may be disrupted. The research focuses on identifying and tuning the connections between transcription factor behavior and gene regulation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with autoimmune diseases or cancers that may be influenced by dysregulated gene expression.
Not a fit: Patients with conditions unrelated to immune disorders or cancer may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating autoimmune diseases and cancers by improving our understanding of gene regulation.
How similar studies have performed: Other research has shown promise in using optogenetics and single-cell sequencing to study gene regulation, indicating that this approach could yield valuable insights.
Where this research is happening
RALEIGH, UNITED STATES
- NORTH CAROLINA STATE UNIVERSITY RALEIGH — RALEIGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CAYWOOD, LEANDRA — NORTH CAROLINA STATE UNIVERSITY RALEIGH
- Study coordinator: CAYWOOD, LEANDRA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases, Cancers