Understanding how cells repair dangerous DNA damage
Mechanisms of Human DNA Double-Strand Break Repair via Quantitative Single-Molecule Imaging
This study is looking at how our cells fix serious DNA damage that can lead to cancer, and it aims to understand how these repair processes might affect how well patients respond to chemotherapy, with the hope of finding better ways to treat cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11012014 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which human cells repair double-strand breaks in DNA, a critical type of damage that can lead to cancer. By using advanced imaging techniques, the study aims to uncover how these repair processes work at a molecular level, particularly in the context of cancer treatment. The research focuses on two main pathways of DNA repair and how mutations in these pathways can affect patient responses to chemotherapy. This knowledge could help identify new therapeutic targets and improve cancer treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients with advanced cancers who are undergoing or have undergone chemotherapy and may have mutations affecting DNA repair pathways.
Not a fit: Patients with early-stage cancers or those not receiving chemotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer therapies by enhancing our understanding of DNA repair mechanisms and how they influence treatment responses.
How similar studies have performed: Other research has shown promising results in understanding DNA repair mechanisms, suggesting that this approach could yield valuable insights and advancements in cancer treatment.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Rothenberg, Eli — New York University School of Medicine
- Study coordinator: Rothenberg, Eli
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.