Understanding how cells organize during development and disease
Official title: Investigating mechanisms of tissue polarity during development and disease
Funded at Pennsylvania State Univ Hershey Med Ctr · NIH-10931356 · Data updated 2026-11-12
This study is looking at how certain proteins help cells work together properly during development, and it aims to understand how problems with this process can lead to serious issues like heart and spinal defects, using mice to learn more about these important cell interactions.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State Univ Hershey Med Ctr NIH-funded |
| Lab location | 1 site (Hershey, United States) |
| Project start | November 1, 2023 |
| Project end | October 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $36,017 |
| NIH project number | 5F31HD113262-02 |
| Project ID | NIH-10931356 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic predispositions to developmental disorders or those affected by conditions related to cell signaling disruptions.
✕Less likely to help
Patients with conditions unrelated to cell polarity or developmental processes may not benefit from this research.
What this research studies
This research investigates the mechanisms of planar cell polarity (PCP), a crucial signaling pathway that helps cells align and behave collectively during development. By studying how disruptions in PCP can lead to severe developmental defects, such as cardiomyopathies and neural tube defects, the research aims to uncover the role of specific proteins in maintaining proper cell organization. Using mouse models, the team will explore how certain proteins localize at cell borders and how these interactions are regulated during development, which could provide insights into various diseases.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of developmental disorders and potential therapeutic targets for conditions like cardiomyopathies.
How similar studies have gone: Previous research has shown promising results in understanding cell signaling pathways, making this approach both relevant and potentially impactful.
Where this research is happening
-
Pennsylvania State Univ Hershey Med Ctr
Hershey, United States Active
Researchers
- Principal investigator: Stenson, Jazmin — Pennsylvania State Univ Hershey Med Ctr
- Study coordinator: Stenson, Jazmin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.