Understanding how cells manage stress from mitochondrial dysfunction
Official title: Function and regulation of the reductive stress response
Funded at University of California Berkeley · NIH-11125983 · Data updated 2026-11-12
This study is looking at how our cells deal with stress when the tiny powerhouses in them, called mitochondria, aren't working properly, and it's aimed at finding ways to help people with diseases related to this issue by improving how these powerhouses function.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Berkeley NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project start | September 1, 2023 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $309,057 |
| NIH project number | 5R01GM151335-03 |
| Project ID | NIH-11125983 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing conditions related to mitochondrial dysfunction, such as neurodegenerative diseases or age-related decline in health.
✕Less likely to help
Patients with conditions unrelated to mitochondrial function or those who are not experiencing any symptoms of mitochondrial dysfunction may not benefit from this research.
What this research studies
This research investigates how cells respond to stress caused by mitochondrial dysfunction, which is linked to various diseases and aging. It focuses on a specific signaling pathway known as the reductive stress response, which helps regulate the activity of the electron transport chain in mitochondria. By studying the roles of certain proteins involved in this process, the research aims to uncover mechanisms that could prevent or mitigate the effects of mitochondrial-related diseases. Patients may benefit from insights gained about how to enhance mitochondrial function and improve cellular health.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases related to mitochondrial dysfunction and aging.
How similar studies have gone: Previous research has shown promising results in understanding mitochondrial signaling pathways, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California Berkeley
Berkeley, United States Active
Researchers
- Principal investigator: Rape, Michael P — University of California Berkeley
- Study coordinator: Rape, Michael P
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.