Understanding how cells manage iron and manganese levels
New tools to probe iron and manganese homeostasis in bacterial and eukaryotic cells
This study is looking at how our cells and bacteria manage important metals like iron and manganese, which are vital for our health, and it hopes to find new ways to help treat diseases like neurodegenerative disorders that can happen when these metals are out of balance.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State University, the NIH-funded |
| Lab location | 1 site (University Park, United States) |
| Project ID | NIH-10913523 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which bacterial and human cells regulate iron and manganese, two essential metal ions. It focuses on the complex systems that control the uptake and export of these metals, which are crucial for cellular function and avoiding toxicity. By developing metal-selective fluorescent sensors, the study aims to gain insights into how disruptions in metal homeostasis can lead to diseases, particularly neurodegenerative disorders. The findings could pave the way for new therapeutic strategies to manage these conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with neurodegenerative disorders or those affected by bacterial infections where metal ion regulation is implicated.
Not a fit: Patients with conditions unrelated to iron or manganese homeostasis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for neurodegenerative diseases and bacterial infections linked to metal ion mismanagement.
How similar studies have performed: Previous research has shown promising results in understanding metal ion regulation and its implications for health, suggesting that this approach could yield valuable insights.
Where this research is happening
University Park, United States
- Pennsylvania State University, the — University Park, United States (Active)
Researchers
- Principal investigator: Cotruvo, Joseph Alfred — Pennsylvania State University, the
- Study coordinator: Cotruvo, Joseph Alfred
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.